Accession Number : ADA337889

Title :   Characterization of CTL Recognized Epitopes on Human Breast Tumors

Descriptive Note : Annual rept. 19 Aug 96-18 Aug 97

Corporate Author : M D ANDERSON CANCER CENTER HOUSTON TX

Personal Author(s) : Ioannides, Constantin G.

PDF Url : ADA337889

Report Date : SEP 1997

Pagination or Media Count : 153

Abstract : Studies during the current granting period lead to the following major findings: (1) identification of a novel tumor Ag for breast and ovarian CTL from the folate binding protein (FBP) with a dominant HLA-A2-epitope E39 (FBP, 191-199); (2) identification of Th1 epitope from HER-2 that induces IFN-gamma preferentially when recognized in association with HLA-DR4; (3) establishment of approaches for (a) culture of breast TIL from small primary tumors and (b) HPLC fractionation and epitope reconstitution from breast tumors.

Descriptors :   *CYTOTOXINS, *T LYMPHOCYTES, *BREAST CANCER, HUMANS, PEPTIDES, PROTEINS, NEOPLASMS, THERAPY, GENES, IMMUNITY, CELLS(BIOLOGY), LYMPHOCYTES, MAMMARY GLANDS.

Subject Categories : Biochemistry
      Medicine and Medical Research
      Toxicology

Distribution Statement : APPROVED FOR PUBLIC RELEASE