Accession Number : ADA337889
Title : Characterization of CTL Recognized Epitopes on Human Breast Tumors
Descriptive Note : Annual rept. 19 Aug 96-18 Aug 97
Corporate Author : M D ANDERSON CANCER CENTER HOUSTON TX
Personal Author(s) : Ioannides, Constantin G.
PDF Url : ADA337889
Report Date : SEP 1997
Pagination or Media Count : 153
Abstract : Studies during the current granting period lead to the following major findings: (1) identification of a novel tumor Ag for breast and ovarian CTL from the folate binding protein (FBP) with a dominant HLA-A2-epitope E39 (FBP, 191-199); (2) identification of Th1 epitope from HER-2 that induces IFN-gamma preferentially when recognized in association with HLA-DR4; (3) establishment of approaches for (a) culture of breast TIL from small primary tumors and (b) HPLC fractionation and epitope reconstitution from breast tumors.
Descriptors : *CYTOTOXINS, *T LYMPHOCYTES, *BREAST CANCER, HUMANS, PEPTIDES, PROTEINS, NEOPLASMS, THERAPY, GENES, IMMUNITY, CELLS(BIOLOGY), LYMPHOCYTES, MAMMARY GLANDS.
Subject Categories : Biochemistry
Medicine and Medical Research
Distribution Statement : APPROVED FOR PUBLIC RELEASE