Accession Number : ADA338248

Title :   Genetic Immunization for Lentiviral Immunodeficiency Virus Infection and Disease

Descriptive Note : Annual rept. 30 Sep 96-29 Oct 97

Corporate Author : CALIFORNIA UNIV DAVIS

Personal Author(s) : Gardner, Murray B.

PDF Url : ADA338248

Report Date : NOV 1997

Pagination or Media Count : 17

Abstract : Work proceeded well during the past year. Our experiment to optimize DNA vaccination in primates has been completed and almost all samples are analyzed. We found that optimal DNA vaccination conditions in Macaques are quite different from those that most workers are using and this could account for the weak and transient responses and lack of protection observed to date. We have also completed the design of the challenge experiment and have been vaccinating animals with SIVmac env containing plasmids. We collected samples at monthly intervals and now are in the 4th month post-vaccination. Animals will be reinjected in December and challenged with SIVmac 251 February, 1998.

Descriptors :   *VIRUS DISEASES, *IMMUNITY, DEOXYRIBONUCLEIC ACIDS, PLASMIDS, ANIMALS, PRIMATES, HUMAN IMMUNODEFICIENCY VIRUSES, LOW STRENGTH, GENETICS, VACCINES, ARBOVIRUSES, MACAQUE MONKEYS.

Subject Categories : Microbiology
      Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE