Accession Number : ADA338761
Title : Estrogen Effects on Breast Tumor Growth in Estrogen Receptor-Minus Mice
Descriptive Note : Annual rept. 15 Aug 96-14 Aug 97
Corporate Author : MISSOURI UNIV-COLUMBIA
Personal Author(s) : Lubahan, Dennis
PDF Url : ADA338761
Report Date : SEP 1997
Pagination or Media Count : 21
Abstract : Although nearly half of human breast cancers at diagnosis are estrogen-responsive and respond to antiestrogen therapy at least for a time, more than half are estrogen receptor negative (ER-) and are predicted to be estrogen- nonresponsive tumors. However, some tumors which are ER-appear to respond to antiestrogen therapy in patients, which is beneficial because antihormonal therapy is less toxic than the alternative chemotherapy. The SCID mouse model has been recently used to study the hormonal dependence of growth of human breast cancer cells as tumors. Recent work has identified a potential model system where ER- breast cancer cells are estrogen- independent in cell culture, and yet intriguingly show estrogen-stimulated growth as tumors in SCID mice.
Descriptors : *ESTROGENS, *BREAST CANCER, HORMONES, STIMULATION(PHYSIOLOGY), HUMANS, NEOPLASMS, IN VITRO ANALYSIS, MICE, IN VIVO ANALYSIS, CELLS(BIOLOGY), CULTURES(BIOLOGY), CHEMOTHERAPY, HOSTS(BIOLOGY), MAMMARY GLANDS, ANATOMICAL MODELS, GROWTH(PHYSIOLOGY).
Subject Categories : Biochemistry
Anatomy and Physiology
Medicine and Medical Research
Distribution Statement : APPROVED FOR PUBLIC RELEASE