Accession Number : ADA338767

Title :   Anti-Breast Cancer Effects of Vitamin D3 Analogs Either Alone or in Combination with Other Agents.

Descriptive Note : Annual rept. 1 Oct 96-30 Sep 97,

Corporate Author : CEDARS-SINAI MEDICAL CENTER LOS ANGELESCA

Personal Author(s) : Koeffler, Phillip H.

PDF Url : ADA338767

Report Date : OCT 1997

Pagination or Media Count : 11

Abstract : ,We have studied the effect of vitamin D analogs on growth of various breast cancer cell lines in vitro as well as in vivo and have identified the 19-nor-hexafluoride analogs as being particularly potent in their activity. Furthermore, we have found that vitamin D3 analogs can synergize with Taxol in inhibiting breast cancer. We have recently found that trogliterazone, a synthetic ligand of the peroxisome proliferator/activated receptor y (PPARy) can inhibit the growth of breast cancer cells and this PPARy ligand with All-trans-retinoic acid can induce apoptosis of breast cancer cells. Furthermore, we have looked for genetic alterations of breast cancer including identification of alterations of the cyclin-dependent-kinase inhibitor genes including p27KIPl and the p16' NK4A genes.

Descriptors :   *INHIBITORS, *VITAMIN D, *BREAST CANCER, GROWTH(GENERAL), LIGANDS, ANALOGS, MOLECULAR BIOLOGY, HUMAN BODY, IN VIVO ANALYSIS, CELLS(BIOLOGY).

Subject Categories : Biochemistry
      Anatomy and Physiology
      Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE