Accession Number : ADA338782

Title :   Cell Regulation by a Novel Estrogen Regulated Gene

Descriptive Note : Annual rept. 15 Aug 96-14 Aug 97

Corporate Author : HEALTH RESEARCH INC ALBANY NY

Personal Author(s) : Pentacost, Brian T.

PDF Url : ADA338782

Report Date : SEP 1997

Pagination or Media Count : 24

Abstract : This report describes the work conducted in the first year of a two year IDEA. Our original proposal was funded to study a human estrogen regulated transcript, HEM45, that encodes a novel protein of 181 amino-acid residues (M, 20,300). The HEM45 protein has similarity to the bracket fungus protein FRTl that can cause fruiting-body production and to a Xenopus product, XPMC2, that affects cell-cycle control. These similarities suggest that HEM45 has a role in mediating the estrogen action control of cellular proliferation and differentiation.

Descriptors :   *ESTROGENS, *BREAST CANCER, HUMANS, PEPTIDES, ENZYMES, PROTEINS, ANTIBODIES, GENES, IMMUNE SERUMS, CELLS(BIOLOGY), IMMUNOCHEMISTRY.

Subject Categories : Biochemistry
      Genetic Engineering and Molecular Biology
      Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE