Accession Number : ADA338850

Title :   The RIZ Gene in Human Breast Cancer

Descriptive Note : Annual rept. 1 Sep 96-31 Aug 97

Corporate Author : BURNHAM INST LA JOLLA CA

Personal Author(s) : Huang, Shi

PDF Url : ADA338850

Report Date : SEP 1997

Pagination or Media Count : 16

Abstract : The RIZ gene was isolated based on binding to the retinoblastoma tumor suppressor protein. RIZ gene normally produces two protein products, RIZ1 and RIZ2, that differ in length by the presence or absence of a conserved protein motif, the PR domain, found in a subfamily of Kruppel-like zinc finger genes. RIZ2 lacks the PR domain. RIZ gene maps to human chromosome band 1p36, a region that is commonly deleted or altered in a variety of human cancers including those of breast, neurocrest, colon, and liver tissues. RIZ1 and RIZ2 are widely expressed in normal tissues. However, RIZ1 was undetectable in 4 of 5 breast carcinoma specimens and in 4 of 10 breast cancer cell lines.

Descriptors :   *GENES, *BREAST CANCER, TISSUES(BIOLOGY), HUMANS, PROTEINS, ISOLATION, NEOPLASMS, DEOXYRIBONUCLEIC ACIDS, LIVER, CELLS(BIOLOGY), AMINO ACIDS, SUPPRESSORS, NORMALITY, COLON.

Subject Categories : Biochemistry
      Genetic Engineering and Molecular Biology
      Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE