Accession Number : ADA338874

Title :   Estrogen-Modulated Response of Breast Cancer to Vitamin D and its Analogs: Role of IGF

Descriptive Note : Annual rept. 1 Oct 96-30 Sep 97

Corporate Author : NORTHERN CALIFORNIA INST FOR RESEARCH AND EDUCATION SAN FRANCISCO

Personal Author(s) : Love-Schimenti, Cheryl D.

PDF Url : ADA338874

Report Date : OCT 1997

Pagination or Media Count : 20

Abstract : The purpose is to assess how estrogen (E2) alters the antiproliferative effects of 1,25(OH)2 D3, and to determine how this interaction is modified in the presence of 1C1164,384 (antiestrogen). IGF-I and II exhibit strong proliferative effects on breast cancer cells. The scope herein will determine whether 1 ,25(OH)2 D3 affects IGF-I-R function, or production of its ligand IGF-II, and whether there is a difference in effects on ER+ and ER- cells.

Descriptors :   *VITAMIN D, *ESTROGENS, *BREAST CANCER, STIMULATION(PHYSIOLOGY), ANALOGS, RESPONSE(BIOLOGY), MONOCLONAL ANTIBODIES, CELLS(BIOLOGY), INSULIN, PHOSPHORYLATION.

Subject Categories : Biochemistry
      Anatomy and Physiology
      Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE