Accession Number : ADA338880

Title :   Role of Scavenger Receptors in Uptake of uPA:PAI-1 Complexes in Breast Cancer

Descriptive Note : Annual rept. 16 Sep 96-15 Sep 97

Corporate Author : CALIFORNIA UNIV SAN DIEGO LA JOLLA

Personal Author(s) : Farquhar, Marilyn

PDF Url : ADA338880

Report Date : OCT 1997

Pagination or Media Count : 35

Abstract : This proposal focuses on a novel topic that had not been investigated previously--i.e., potential derangements in expression or trafficking of scavenger receptors, LRP and megalin, and their interactions with uPA-R, uPA and PAI-1 in breast cancer cells. Upon beginning this work, our first order of business was to establish the systems required to carry out the proposed studies and to use them to evaluate the levels of expression of scavenger receptors in breast cancer vs normal cell lines. During the first year of the grant we have prepared several essential reagents (antibodies) and have characterized four cell lines -two estrogen-insensitive and one estrogen-sensitive breast cell lines and one normal mammary cell line.

Descriptors :   *RECEPTOR SITES(PHYSIOLOGY), *PEPTIDE HYDROLASES, *BREAST CANCER, ADHESION, NEOPLASMS, ANTIBODIES, INHIBITORS, IN VIVO ANALYSIS, CELLS(BIOLOGY), MAMMARY GLANDS, GETTERS, METASTASIS.

Subject Categories : Biochemistry
      Anatomy and Physiology
      Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE