Accession Number : ADA338880
Title : Role of Scavenger Receptors in Uptake of uPA:PAI-1 Complexes in Breast Cancer
Descriptive Note : Annual rept. 16 Sep 96-15 Sep 97
Corporate Author : CALIFORNIA UNIV SAN DIEGO LA JOLLA
Personal Author(s) : Farquhar, Marilyn
PDF Url : ADA338880
Report Date : OCT 1997
Pagination or Media Count : 35
Abstract : This proposal focuses on a novel topic that had not been investigated previously--i.e., potential derangements in expression or trafficking of scavenger receptors, LRP and megalin, and their interactions with uPA-R, uPA and PAI-1 in breast cancer cells. Upon beginning this work, our first order of business was to establish the systems required to carry out the proposed studies and to use them to evaluate the levels of expression of scavenger receptors in breast cancer vs normal cell lines. During the first year of the grant we have prepared several essential reagents (antibodies) and have characterized four cell lines -two estrogen-insensitive and one estrogen-sensitive breast cell lines and one normal mammary cell line.
Descriptors : *RECEPTOR SITES(PHYSIOLOGY), *PEPTIDE HYDROLASES, *BREAST CANCER, ADHESION, NEOPLASMS, ANTIBODIES, INHIBITORS, IN VIVO ANALYSIS, CELLS(BIOLOGY), MAMMARY GLANDS, GETTERS, METASTASIS.
Subject Categories : Biochemistry
Anatomy and Physiology
Medicine and Medical Research
Distribution Statement : APPROVED FOR PUBLIC RELEASE