Accession Number : ADA338899

Title :   Deprenyl and Protection Against Mammary Tumors

Descriptive Note : Annual rept. 1 Sep 96-31 Aug 97

Corporate Author : ROCHESTER UNIV NY

Personal Author(s) : Felten, David L.

PDF Url : ADA338899

Report Date : SEP 1997

Pagination or Media Count : 16

Abstract : In the preliminary studies conducted in our laboratory, administration of deprenyl, a monoamine oxidase-B (MAO-B) inhibitor, enhanced immunological functions IN VITRO INTERLEUKIN- 2 (LL-2) production and NK cell activity, reversed the age-related loss of noradrenergic fibers in the spleens of old male rats, and prevented the development of carcinogen-induced mammary tumors in young female rats. The focus of the present study was to investigate whether treatment of young Sprague-Dawley female rats with deprenyl would inhibit the development and growth of 9, 10-dimethyl-1,2-benzanthracene- (DMBA-) induced mammary tumors by augmenting T-cell functions.

Descriptors :   *INHIBITORS, *MONOAMINE OXIDASE, *BREAST CANCER, RATS, NEOPLASMS, IN VITRO ANALYSIS, MALES, CARCINOGENS, T LYMPHOCYTES, IMMUNITY, CELLS(BIOLOGY), FEMALES, SPLEEN, MAMMARY GLANDS, GROWTH(PHYSIOLOGY), PROLACTIN.

Subject Categories : Biochemistry
      Anatomy and Physiology
      Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE