Accession Number : ADA338905
Title : Energy Metabolism in Cold-Stressed Females: Implications for Predictive Modeling
Descriptive Note : Annual rept. 1 Oct 96-30 Oct 97,
Corporate Author : DEFENCE AND CIVIL INST OF ENVIRONMENTALMEDICINE DOWNSVIEW (ONTARIO)
Personal Author(s) : Jacobs, Ira
PDF Url : ADA338905
Report Date : OCT 1997
Pagination or Media Count : 59
Abstract : This document is a progress report which describes the results from the first of a series of studies carried out to clarify the extent 6f gender-related differences in physiological responses to cold stress, and to evaluate the potential implications for survival time in the cold. Specifically, this study was designed to clarify the quantity and quality of energy substrate utilization in shivering female subjects during cold water immersion. The objectives were: to determine the magnitude of metabolic heat production during cold water immersion; to quantify the relative contributions of fat, carbohydrate and protein metabolism to fuelling metabolism; to determine if muscle glycogen is a significant energy source during shivering; to manipulate skeletal muscle glycogen availability and to evaluate the subsequent effects on metabolic rate and body temperature regulation during cold stress. Female subjects were immersed to the neck in 18 deg C water for up t6 90 minutes. Their metabolic rate increased to about 3 times resting levels, similar to what was reported for males. About 40% of metabolism was fueled by carbohydrate oxidation. Muscle glycogen was a significant contributor to metabolism. The protocol was not successful in manipulating glycogen availability.
Descriptors : *METABOLISM, *HYPOTHERMIA, *FEMALES, *SHIVERING, STRESS(PHYSIOLOGY), SUBSTRATES, PHYSIOLOGICAL EFFECTS, FATS, BODY TEMPERATURE, HEAT PRODUCTION(BIOLOGY), CARBOHYDRATE METABOLISM, GLYCOGEN, PROTEIN METABOLISM.
Subject Categories : Anatomy and Physiology
Distribution Statement : APPROVED FOR PUBLIC RELEASE