Accession Number : ADA338927

Title :   Relationship Between Scavenger Receptors and uPA:PAI-l and uPA Receptors in Breast Cancer

Descriptive Note : Annual rept. 15 Sep 96-14 Sep 97

Corporate Author : CALIFORNIA UNIV SAN DIEGO LA JOLLA

Personal Author(s) : Czekay, Ralf-Pater ; Farquhar, Marilyn

PDF Url : ADA338927

Report Date : OCT 1997

Pagination or Media Count : 27

Abstract : The overall goal of this research is to gather detailed information about the cellular distribution and activities of components of the uPA-system in relation to scavenger receptors and RAP in normal and breast cancer cells. We have especially noted a number of differences between the cell lines in either expression levels of these proteins or their localization. Scavenger receptors show higher expression levels in estrogen-insensitive compared to estrogen-sensitive and normal cells. Expression of both receptors seems to correspond with the malignant phenotype of these breast cancer cell lines. Immunocytochemical and immunochemical studies documented similar distribution pattern and expression levels for RAP in all cell lines.

Descriptors :   *RECEPTOR SITES(PHYSIOLOGY), *ENZYME PRECURSORS, *BREAST CANCER, PROTEINS, NEOPLASMS, ANTIBODIES, CELLS(BIOLOGY), ANTIGENS, CYTOCHEMISTRY, IMMUNOCHEMISTRY, ENZYME INHIBITORS, PHOSPHORUS TRANSFERASES.

Subject Categories : Biochemistry
      Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE