Accession Number : ADA338940

Title :   The p16 Pathway In Breast Cancer and Senescence Control

Descriptive Note : Annual rept. 1 Sep 96-31 Aug 97

Corporate Author : M D ANDERSON CANCER CENTER HOUSTON TX

Personal Author(s) : Aldaz, Claudio M.

PDF Url : ADA338940

Report Date : SEP 1997

Pagination or Media Count : 15

Abstract : The main hypothesis of this proposal is that breast cancer cells utilize various alternative mechanisms to circumvent a major restriction point in the G1 phase of cell cycle progression. Furthermore, we speculate that the sum of the various subsets of tumors with abnormalities in either player of the cell cycle inhibitor p16 pathway, accounts for a very significant number of breast cancers. It is a main objective of this research project to elucidate the overall extent of p16 involvement in the tumorigenesis of the breast. An additional major goal is to evaluate whether p16 fulfills all the criteria to be considered a senescence control gene.

Descriptors :   *PROTEINS, *AGING(PHYSIOLOGY), *GENES, *CELLS(BIOLOGY), *BREAST CANCER, PEPTIDES, NEOPLASMS, MUTATIONS, CHROMOSOMES, CODING, INHIBITORS, IN VIVO ANALYSIS, MAMMARY GLANDS, METHYLATION.

Subject Categories : Biochemistry
      Genetic Engineering and Molecular Biology
      Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE