Accession Number : ADA339039

Title :   Breast Mucin Tumor-Specific Epitopes for Cancer Immunotherapy

Descriptive Note : Annual rept. 1 Aug 96-31 Jul 97

Corporate Author : TEXAS TECH UNIV AMARILLO

Personal Author(s) : Dombrowski, Kenneth E.

PDF Url : ADA339039

Report Date : OCT 1997

Pagination or Media Count : 19

Abstract : The objectives of the research program are to study the structure-immunogenicity relationships of a hypoglycosylated human tumor-specific mucin common to breast and other adenocarcinomas. Hypo-glycosylation of breast mucin leads to exposure of a tumor-specific epitope (TSE). The structural and immunogenic properties of the TSE are being examined using synthetic mucin peptides and recombinant mucin proteins that contain the TSE and/or mutations in potential glycosylation sites surrounding the TSE.

Descriptors :   *IMMUNIZATION, *MUCIN, *BREAST CANCER, STRUCTURAL PROPERTIES, PEPTIDES, PROTEINS, NEOPLASMS, MUTATIONS, RESPONSE, THERAPY, ANTIBODIES, MONOCLONAL ANTIBODIES, CELLS(BIOLOGY), CARBOHYDRATES, ANTIGENS, VACCINES, SUGARS, MAMMARY GLANDS, IMMUNOGENS.

Subject Categories : Biochemistry
      Medicine and Medical Research
      Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE