Accession Number : ADA339104

Title :   Expression of the Epidermal Growth Factor Receptor Family in Transgenic Mouse Models of Human Breast Cancer

Descriptive Note : Annual rept. 1 Aug 96-31 Jul 97

Corporate Author : MCMASTER UNIV HAMILTON (ONTARIO)

Personal Author(s) : Miller, William J.

PDF Url : ADA339104

Report Date : AUG 1997

Pagination or Media Count : 20

Abstract : Transgenic mice expressing the activated neu oncogene in the mammary epithelium develop mammary tumors with relatively short latency. To explore the role of the EGFR in tumorigenesis in this system we have recently crossed these MMTV/activated neu strains to a naturally occurring mouse mutant which expresses a catalytically inactive EGFR (Waved-2 strain).

Descriptors :   *EPITHELIUM, *GROWTH(PHYSIOLOGY), *BREAST CANCER, TISSUES(BIOLOGY), HUMANS, NEOPLASMS, CELLS(BIOLOGY), EPIDERMIS, MAMMARY GLANDS, PHOSPHORUS TRANSFERASES.

Subject Categories : Biochemistry
      Anatomy and Physiology
      Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE