Accession Number : ADA339111

Title :   Use of Cytokines to Prevent Breast Cancer Growth and Progression

Descriptive Note : Annual rept. 1 Aug 96-31 Jul 97

Corporate Author : HENRY M JACKSON FOUNDATION ROCKVILLE MD

Personal Author(s) : Grimley, Philip M.

PDF Url : ADA339111

Report Date : AUG 1997

Pagination or Media Count : 24

Abstract : The current project extends two sets of observations: (1) Original work from our laboratories which showed that a cytoplasmic extract from transformed cells (TKO) interrupts the Stat1 signal transduction pathway of IFN-alpha/beta 28; and (2) published work of others showing that human breast cancer cells can secrete PRL and thus might autonomously activate Stat 1 by tyrosine phosphorylation.

Descriptors :   *PEPTIDES, *IMMUNITY, *CELLS(BIOLOGY), *GROWTH(PHYSIOLOGY), *BREAST CANCER, HUMANS, CYTOPLASM, RESPONSE(BIOLOGY), IMMUNIZATION, INSULIN, TYROSINE, PHOSPHORYLATION.

Subject Categories : Biochemistry
      Anatomy and Physiology
      Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE