Accession Number : ADA339111
Title : Use of Cytokines to Prevent Breast Cancer Growth and Progression
Descriptive Note : Annual rept. 1 Aug 96-31 Jul 97
Corporate Author : HENRY M JACKSON FOUNDATION ROCKVILLE MD
Personal Author(s) : Grimley, Philip M.
PDF Url : ADA339111
Report Date : AUG 1997
Pagination or Media Count : 24
Abstract : The current project extends two sets of observations: (1) Original work from our laboratories which showed that a cytoplasmic extract from transformed cells (TKO) interrupts the Stat1 signal transduction pathway of IFN-alpha/beta 28; and (2) published work of others showing that human breast cancer cells can secrete PRL and thus might autonomously activate Stat 1 by tyrosine phosphorylation.
Descriptors : *PEPTIDES, *IMMUNITY, *CELLS(BIOLOGY), *GROWTH(PHYSIOLOGY), *BREAST CANCER, HUMANS, CYTOPLASM, RESPONSE(BIOLOGY), IMMUNIZATION, INSULIN, TYROSINE, PHOSPHORYLATION.
Subject Categories : Biochemistry
Anatomy and Physiology
Medicine and Medical Research
Distribution Statement : APPROVED FOR PUBLIC RELEASE