Accession Number : ADA339114

Title :   Amplified Genes in Breast Cancer: Molecular Targets for Investigation and Therapy

Descriptive Note : Annual rept. 1 Sep 96-31 Aug 97

Corporate Author : SALK INST FOR BIOLOGICAL STUDIES LA JOLLA CA

Personal Author(s) : Wahl, geoffrey M.

PDF Url : ADA339114

Report Date : AUG 1997

Pagination or Media Count : 21

Abstract : We showed that extrachromosomally amplified genes in double minute chromosomes (DMs) are removed from tumor cells through preferential incorporation into micronuclei that are generated in S-phase. This process is enhanced by DNA synthesis inhibitors, and requires p53 inactivation. In the past year, we developed technology that enables visualization of chromosome dynamics in living cells.

Descriptors :   *GENES, *BREAST CANCER, NEOPLASMS, TARGETS, DEOXYRIBONUCLEIC ACIDS, CHROMOSOMES, THERAPY, MOLECULAR BIOLOGY, AMPLIFICATION, INHIBITORS, LIFE(BIOLOGY), CELLS(BIOLOGY), BIOSYNTHESIS, HISTONES.

Subject Categories : Biochemistry
      Genetic Engineering and Molecular Biology
      Anatomy and Physiology
      Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE