Accession Number : ADA954467

Title :   Immunological Studies on Heroin Addiction.

Descriptive Note : Annual rept. Aug 73-Jun 74,

Corporate Author : PUBLIC HEALTH RESEARCH INST OF THE CITY OF NEW YORK INC

Personal Author(s) : Liu,C. T. ; Adler,F. L.

Report Date : JUN 1974

Pagination or Media Count : 28

Abstract : Hemagglutination-inhibition (HI) procedures for the detection and measurement of several abused drugs have been further developed and evaluated. Tests for morphine and for methadone have been applied to more than 30,000 urine specimens. The HI test for barbiturates is operational but requires further work toward increased sensitivity. AN HI test for ecgonine has been shown to detect this drug and benzoylecgonine in urines containing 30 ng/ml or more of these drugs but suitable antisera have proven to be difficult to prepare. Preliminary results suggest the feasibility of detecting LSD by HI. The results of further studies on sporadic recurrent excretion of morphine are reported. Also presented are data which illustrate individual-specific responses to drug protein conjugates. Progress toward the use of immunoadsorbants for concentration and purification of drugs in biological fluids is also reported.

Descriptors :   ANTIBODIES, BARBITURATES, DETECTION, DRUG ADDICTION, DRUGS, EXCRETION, FEASIBILITY STUDIES, FLUIDS, HEROIN, IMMUNE SERUMS, IMMUNOLOGY, MORPHINE, PROTEINS, PURIFICATION

Subject Categories : Medicine and Medical Research
      Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE