Accession Number : ADA954482

Title :   The Treatment of Shock Based upon Physiological Principles and Impedence Method for Measuring Cardiac Output in Shock.

Descriptive Note : Annual progress rept. 1 Jan-31 Dec 64,

Corporate Author : MINNESOTA UNIV MINNEAPOLIS

Personal Author(s) : Lillehei,R. C.

Report Date : JAN 1965

Pagination or Media Count : 9

Abstract : In the shock syndrome, various initial stresses lead to a common, hemodynamic pathway of severely reduced tissue perfusion with hypoxemia and acidosis. The goal in shock treatment is to restore a state of circulatory balance in which the volume of blood perfusing tissue, especially certain vital viscera, carries with it enough oxygen to meet the tissue metabolic requirement for oxygen (MRO2). Metabolic acidosis is a consequence of hypoxemia and is best corrected by restoring adequate tissue oxygenation. Cardiac output is reduced by interfering directly with myocardial contractility; by altering coronary artery perfusion pressure and by altering the distribution of oxygenated blood to e myocardium. For the past year, we have focused our attention to the elaboration and dissection of some of the cardiac mechanisms operating in shock. Investigations of the treatment of shock based upon physiological principles have proceeded in three phases: Hemorrhagic Shock; (2) Gram-negative bacterial endotoxinemic shock and Cardiogenic Shock. Models of each have been developed and standardized in the dog, and treatment methods have been studied with respect to circulatory hemodynamics, biochemical changes and survival value. Originator supplied keywords include: Shock; Cardiac output; Blood volume; Peripheral resistance.

Descriptors :   ACIDOSIS, BALANCE, BLOOD, BLOOD CIRCULATION, BLOOD VOLUME, CARDIOVASCULAR SYSTEM, CONTRACTION, CORONARY ARTERIES, DISSECTION, DOGS, HEART, HEART FUNCTION TESTS, HEMORRHAGIC SHOCK, HYPOXIA, MEASUREMENT, METABOLIC DISEASES, MYOCARDIUM, OXYGEN, PERFUSION, PRESSURE, RESISTANCE, SHOCK(PATHOLOGY), SIGNS AND SYMPTOMS, STRESSES, SURVIVAL(GENERAL), VALUE, VOLUME

Subject Categories : Anatomy and Physiology
      Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE