Accession Number : ADA954875

Title :   Study of African Trypanosomiasis.

Descriptive Note : Final rept. 1 Sep 73-31 Aug 74,

Corporate Author : ARMY MEDICAL RESEARCH UNIT-KENYA APO NEW YORK 09675

Personal Author(s) : Muriithi,I.

Report Date : 01 SEP 1974

Pagination or Media Count : 12

Abstract : Calves have been immunized for varying periods of time by passive transfer of immune T4 rhodesiense serum. Immunized animals and controls were challenged with 1 x 10 trypanosomes from infected rats. Those immunized failed to develop demonstrable infection whereas controls did. In Lambwe Valley (western Kenya by Lake Victoria) isolates of T. rhodesiense were collected from human cases and injected into rats. Parasites from human cases in Ethiopia and Tanzania as well as from 83 cattle (T. brucei) were all tested by neutralization (Solytes) with antisera collected from bovines which had undergone longterm infection with various isolates. All four isolates from Lambwe Valley appear to be antigenically similar since antiserum to one neutralized all others within the limits of our tests. When isolates from T. brucei from cattle were tested, the antiserum showed a strong effect against three of the nine isolates indicating that these cattle were infected with the same strain as the four humans. New investigations of the feasibility of practical artificial immunization by the use of irradiated trypanosomes and on the pathophysiological process occurring in trypanosomiasis in cattle are underway. (Author).

Descriptors :   AFRICA, ANIMALS, ANTIBODIES, BOVINES, ETHIOPIA, HUMANS, IMMUNE SERUMS, IMMUNIZATION, INFECTIOUS DISEASES, IRRADIATION, KENYA, LONG RANGE(TIME), NEUTRALIZATION, PARASITES, PASSIVE SYSTEMS, PATHOLOGY, PHYSIOLOGY, RATS, TANZANIA, TRANSFER, TRYPANOSOMA, TRYPANOSOMIASIS

Subject Categories : Anatomy and Physiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE