Accession Number : ADA954876

Title :   Development and Investigation of a Cell Culture Model of Morphine Addiction.

Descriptive Note : Final rept.,

Corporate Author : MINNESOTA UNIV MINNEAPOLIS

Personal Author(s) : Estensen,R. D.

Report Date : 15 SEP 1974

Pagination or Media Count : 19

Abstract : Initial experiments were directed to finding a morphine effect on growth of Novikoff Hepatoma cells. Data obtained provided the information that between 5x10 to the minus 4 and 10 to the minus 3m morphine sulfate were growth inhibitory. Further experiments did not reproduce initial success. We then switched to a fibroblastic cell type--mouse L cells. Initial results were encouraging, indicating that some dependence of L cells on the presence of morphine developed. Again repeated experiments failed to show this phenomenon.

Descriptors :   CELLS(BIOLOGY), CULTURES(BIOLOGY), DRUG ADDICTION, GROWTH(GENERAL), LIVER, MODELS, MORPHINE, NEOPLASMS

Subject Categories : Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE