Accession Number : ADA954892

Title :   Biochemical Relationships between Malaria Parasites and Their Host Erythrocytes.

Descriptive Note : Final rept. 1 Sep 71-31 Aug 72,

Corporate Author : ROCKEFELLER UNIV NEW YORK

Personal Author(s) : Trager,W. ; Kilejian,A.

Report Date : MAR 1973

Pagination or Media Count : 7

Abstract : Extracellular development of malaria parasites in vitro was found to be affected in a specific way by bongkrekic acid, an antibiotic known to interfere with adenine nucleotide translocation in mitochondria. The DNA of Plasmodium lophurae was found to have a minor satellite band of buoyant density higher than that of the main band. Methods for separation of the membranes of malaria parasites have been developed with the aim of characterizing their enzymatic activities.

Descriptors :   ADENINE, BUOYANCY, DENSITY, IN VITRO ANALYSIS, MALARIA, MITOCHONDRIA, NUCLEOTIDES, PARASITES, TRANSLOCATION

Subject Categories : Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE