Accession Number : ADA954917

Title :   Formation of Debri (Platelet, White Cell, Fibrin Aggregates) in Stored Blood: Physiological Significance and Removal by Filtration.

Descriptive Note : Final rept.,

Corporate Author : QUEEN'S MEDICAL CENTER HONOLULU HAWAII

Personal Author(s) : McNamara,J. J.

Report Date : MAR 1973

Pagination or Media Count : 26

Abstract : Blood stored at 4 degrees C. in ACD solution has been shown to develop microaggregates composed primarily of platelets and fibrin. This debris in transfused blood has been shown to produce changes in pulmonary hemodynamics in animals and has been implicated in the pathogenesis of post-traumatic pulmonary insufficiency in man. The present studies were undertaken to more clearly define the mechanism by which these microaggregates are formed. It is directed primarily at studying evolutionary changes in platelet function and fibrinogen composition of stored human blood.

Descriptors :   ANIMALS, BLOOD, BLOOD CIRCULATION, BLOOD PLATELETS, BLOOD STORAGE, FIBRIN, FILTRATION, FUNCTIONS, HUMANS, LUNG, PATHOGENESIS, REMOVAL

Subject Categories : Anatomy and Physiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE