Accession Number : ADA955147
Title : The Effect of Hypoxia on the Pulmonary Microcirculation.
Descriptive Note : Rept. no. 1 (Annual) 1 Oct 67-30 sep 68,
Corporate Author : COLORADO UNIV AT DENVER MEDICAL CENTER
Personal Author(s) : Wagner,Wiltz W. , Jr
Report Date : 30 SEP 1968
Pagination or Media Count : 15
Abstract : A technique designed to permit direct microscopic observation via a transparent window implanted in the chest wall of dogs of the pulmonary capillaries in vivo has been developed. Cine- and photomicrographic techniques have been developed to permit high speed, high resolution study of the pulmonary microcirculation. These systems have been designed to provide information related to the following: (1) The velocity of the erythrocytes as they cross the alveolar capillary net to determine contact time between oxygen and hemoglobin, (2) the orientation of the erythrocytes in the capillaries to determine the intracapillary diffusion distance of molecular oxygen; (3) the site of action of the hypoxic vasopressor response, and; (4) the quantitation of the oxyhemoglobin gradient along the microcirculation to determine (a) the boundaries of the oxygen uptake process, (b) the shape of the uptake curve, and (c) how the curve and boundaries are affected by stress, e.g. hypoxemia or exercise.
Descriptors : ALVEOLI, CAPILLARIES(ANATOMY), CAPILLARY TUBES, DIFFUSION, DOGS, ERYTHROCYTES, GRADIENTS, GRAPHS, HEMOGLOBIN, HIGH RESOLUTION, HIGH VELOCITY, HYPOXIA, IN VIVO ANALYSIS, LUNG, MOLECULAR PROPERTIES, ORIENTATION(DIRECTION), OXYGEN, OXYGEN CONSUMPTION, PHOTOMICROGRAPHY, RANGE(DISTANCE), SITES, THORAX, TRANSPARENCE, VELOCITY, WALLS, WINDOWS
Subject Categories : Anatomy and Physiology
Distribution Statement : APPROVED FOR PUBLIC RELEASE