Accession Number : ADA955163
Title : Antigen Transport.
Descriptive Note : Final rept. 1 Jul 68-31 Aug 70,
Corporate Author : NEBRASKA UNIV AT OMAHA COLL OF MEDICINE
Personal Author(s) : Ryan,Wayne L.
Report Date : 08 FEB 1971
Pagination or Media Count : 48
Abstract : Antiserum to nuclei, microsomes, mitochondria and lysosomes was prepared. The antisera were in an allograft system. Only the lysosomal antiserum was found to suppress the allograft response. Protein transport in macrophages was studied. Denaturation and the degree of iodination was found to influence protein transport. A series of antigens were tested for immunogenicity. The same antigens were subjected to hydrolysis by cathepsins. The most immunogenic of the antigens were not hydrolyzed by the cathepsins and the least immunogenic were hydrolyzed extensively.
Descriptors : ANTIBODIES, ANTIGENS, CELL STRUCTURE, IMMUNE SERUMS, IMMUNOGENS, IODINATION, MICROSOMES, MITOCHONDRIA, NUCLEI, PROTEINS, RESPONSE, SURGICAL TRANSPLANTATION, TRANSPORT
Subject Categories : Medicine and Medical Research
Distribution Statement : APPROVED FOR PUBLIC RELEASE