Accession Number : ADA955165
Title : A Study of Tolerance and Safety of a Combination of Anti-Malarial Drugs in Young Adult Males.
Descriptive Note : Final rept. 9 Mar 70-31 May 72,
Corporate Author : FLORIDA UNIV GAINESVILLE COLL OF MEDICINE
Personal Author(s) : Weiss,Charles F.
Report Date : 04 AUG 1972
Pagination or Media Count : 37
Abstract : The purpose of this study was to determine the safety for extended use in humans of 4,4'diformamidodiphenylsulfone (DFD) an antimalarial drug proven effective if given once a week with chloroquine-primaquine. Currently, the usual treatment for malaria utilizes another sulfone, diaminodiphenylsulfone (DDS) in combination with chloroquine-primaquine. However, to maintain effectiveness, DDS must be given daily. DFD, requiring only weekly administration, offers an obvious advantage. It is concluded that long-term (up to 52 weeks) administration of DFD to male prison volunteers had no serious untoward effects. There is no build-up of the drug as a result of a single weekly oral dose of 800 mg.
Descriptors : ACCUMULATION, ADULTS, ANTIMALARIALS, DOSAGE, DRUGS, MALARIA, MALES, MOUTH
Subject Categories : Pharmacology
Distribution Statement : APPROVED FOR PUBLIC RELEASE