Accession Number : ADA955923

Title :   Immunopathology of Malaria and Other Hemosporidian Infections.

Descriptive Note : Annual progress rept. no. 3, 1 Oct 67-30 Sep 68,

Corporate Author : MICHIGAN STATE UNIV EAST LANSING DEPT OF MICROBIOLOGY AND PUBLIC HEALTH

Personal Author(s) : Cox, Herbert W. ; Corwin, Robert M.

Report Date : 01 DEC 1968

Pagination or Media Count : 14

Abstract : The solution sought in this research project is the discovery of the mediators of disease, anemia, splenomegaly, petechial hemorrhage and nephritis in human malaria. The approach is based on the concept that disease is mediated by in vivo immunologic reactions rather than by toxic substances elaborated by the parasites. This concept has received general acceptance in cases of most of the infectious diseases caused by fungi, bacteria, rickettsiae or the viruses. However, in the cases of malaria, the immunologic mechanisms are obscure. Thus in this project, research must be directed at discovering and defining the immune mechanisms, and then to seek for a causal relationship between the allergic state and/or the antibodies of immunity and the diseases associated with malaria. Keywords: Immunopathology, Malaria, Hemosporidian infections, Medical research, U/A Reports. (JG)

Descriptors :   *IMMUNITY, *INFECTIOUS DISEASES, *MALARIA, *PATHOLOGY, *HEMOSPORIDIA, ACCEPTABILITY, ALLERGIC DISEASES, ANEMIAS, ANTIBODIES, BACTERIA, DISEASES, FUNGI, HEMORRHAGE, HUMANS, IMMUNOLOGY, IN VIVO ANALYSIS, MEDICAL RESEARCH, NEPHRITIS, PARASITES, SPLENOMEGALY, TOXICITY, VIRUSES.

Subject Categories : Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE