Accession Number : ADA955926

Title :   Toxicity Testing of Antimalarial Drugs in Swine. I. A Study of Quinine Sulfate Toxicity.

Descriptive Note : Annual rept.,

Corporate Author : TEXAS A AND M UNIV COLLEGE STATION DEPT OF VETERINARY PATHOLOGY

Personal Author(s) : Bay, William W. ; Gleiser, Chester A. ; Dukes, Thomas W. ; Pierce, Kenneth R. ; Brown, Randolph S.

Report Date : 30 JUN 1967

Pagination or Media Count : 24

Abstract : Quinine sulfate administered orally to swine in doses of 361 mg/kg/day (milligrams/kilograms/day) resulted in an LD 100/10 (Lethal dose 100/10), whereas, 180 mg/kg/day produced death in one of four pigs in 30 days, and no ill effects were observed in animals that received 45 mg/kg/day for 30 days. The most consistent symptoms observed were: emesis, depression, ataxia, partial to complete loss of sight and convulsions. The hematologic and biochemical results were very unimpressive, with few changes. The significant gross lesions may be summarized as: a hemorrhagic disorder, corneal lesions and alopecia. The most significant microscopic lesions are vacuolization of neurons, corneal lesions, bone marrow lesions and degenerative lesions of the arteriolar walls. Keywords: U/A Reports, Toxicity, Antimalarial, Drugs, Swine, Testing, Pharmacology, Quinine sulfate, Medical research. (jg)

Descriptors :   *ANTIMALARIALS, *QUININE, *SULFATES, *TOXICITY, ALOPECIA, ANIMALS, ATAXIA, BIOCHEMISTRY, BONE MARROW, CONSISTENCY, CONVULSIVE DISORDERS, CORNEA, DEATH, DOSAGE, DRUGS, EMESIS, HEMATOLOGY, HEMORRHAGE, LESIONS, LOSSES, MEDICAL RESEARCH, MICROSCOPY, ORDER DISORDER TRANSFORMATIONS, PHARMACOLOGY, SIGHTS, SIGNS AND SYMPTOMS, SWINE, TEST AND EVALUATION, WALLS.

Subject Categories : Pharmacology
      Toxicology

Distribution Statement : APPROVED FOR PUBLIC RELEASE