Accession Number : ADB024470

Title :   Prevention of Influenza and other Respiratory Diseases.

Descriptive Note : Annual progress rept. 1 Nov 76-30 Jun 77,

Corporate Author : COLORADO UNIV AT DENVER MEDICAL CENTER

Personal Author(s) : Meiklejohn, Gordon ; Eickhoff, Theodore C.

Report Date : AUG 1977

Pagination or Media Count : 34

Abstract : This report summarizes a study of a population of about 9000 individuals at Lowry AFB. Illness rates due to the 1977 influenza A strains were low (about 5%) in unvaccinated young adults. Illness rates were considerably lower in persons who had received vaccine containing 400 CCA units of A/Victoria/3/75. Vaccine efficacy, by the lowest estimate, was 73%, and was probably considerably higher. The new influenza A strain, as represented by A/Denver/1/77 did not spread into the surrounding civilian community. Data currently available indicate that A/Victoria/75 vaccine provided a high level of protection, and that a change in vaccine composition is not necessary. A modest outbreak of influenza B occurred in the metropolitan Denver civilian community, and was reflected by a small number of cases of influenza B that occurred at Lowry AFB, primarily in permanent party personnel. A significant rubella outbreak occurred during January and February, 1977, among both male and female students at Lowry AFB. Despite outbreaks of influenza A and rubella, the incidence of febrile respiratory disease at Lowry AFB remain generally low. Adenovirus illness was virtually absent, and streptococcal pharyngitis occurred at only a low level. Investigations are continuing to define the reasons for the unexpected HI antibody response to PR8 antigen in sera of students who received A/New Jersey/76 vaccine.

Descriptors :   *VACCINES, *INFLUENZA VIRUS, STRAINS(BIOLOGY), DRIFT, ANTIGENS, RESPIRATORY DISEASES, EPIDEMIOLOGY, RUBELLA, YOUTH, AIR FORCE PERSONNEL, CIVILIAN POPULATION, STUDENTS, AIR FORCE FACILITIES, COLORADO, PREVENTIVE MEDICINE, NEURAMINIC ACID, ANTIBODIES.

Subject Categories : Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE