Accession Number : ADB026116

Title :   Prevention of Influenza and Other Respiratory Diseases.

Descriptive Note : Annual progress rept. 1 Jul 77-31 Jan 78,

Corporate Author : COLORADO UNIV AT DENVER MEDICAL CENTER

Personal Author(s) : Meiklejohn, Gordon ; Eickhoff, Theodore C.

Report Date : FEB 1978

Pagination or Media Count : 33

Abstract : Antibody studies on 23 unvaccinated and 30 vaccinated persons with A/Texas/77 influenza showed that almost all had been infected previously with H3N2 strains. HI titers were highest against the earliest strain and diminished progressively with more recent strains. They were lowest with A/Denver/77, the epidemic strain. Neuraminidase inhibiting (NI) antibody titers were low in the acute sera of unvaccinated persons, but 15 of 33 vaccinated persons had titers of > or = 16. The NI titer levels were of less value in predicting protection against influenza illness that HI antibody levels against the epidemic strain. The most useful tests for serodiagnosis were HI tests using the epidemic strain and complement-fixation tests. NI tests and HI tests with earlier H3N2 strains were less sensitive, particularly in vaccinated persons. The Lowry Air Force Base population, which had received A/Victoria/75 vaccine in November, 1977 had only a scattering of cases of influenza even though influenza A, mainly A/Victoria/75, was widespread in the Denver area in December, 1977 and January, 1978. HI tests for antibody for H1N1 strains showed that persons under 23 years of age lacked antibody for A/FM1/47, A/AA/57 or the new epidemic strain A/USSR/90/77. A large proportion of persons between 23 and 32 and a smaller proportion of older persons had antibody. Titers were considerably higher for A/FM1/47 than for A/AA/57 or A/USSR/90/77.

Descriptors :   *INFLUENZA VIRUS, *VACCINES, *PREVENTIVE MEDICINE, ADENOVIRUSES, ANTIBODIES, RESPIRATORY DISEASES, STRAINS(BIOLOGY), EPIDEMIOLOGY, SERODIAGNOSIS.

Subject Categories : Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE