Accession Number : ADB039812

Title :   Teratogenicity of Dimethylmorpholinophosphoramidate (DMMPA) and Diethylmorpholinophosphoramidate (DEMPA) in Rats.

Descriptive Note : Technical rept. Aug 77-Apr 78,

Corporate Author : ARMY ARMAMENT RESEARCH AND DEVELOPMENT COMMAND ABERDEEN PROVING GROUND MD CHE MICAL SYSTEMS LAB

Personal Author(s) : Starke, William C. ; Pellerin, Ronald J.

Report Date : JUN 1979

Pagination or Media Count : 17

Abstract : The teratogenic potentials of dimethylmorpholinophosphoramidate (DMMPA) and diethylmorpholinophosphoramidate (DEMPA) were investigated in the rat. Oral doses accumulating to 1.0 and 0.1 LD50 for each compound were administered over the 10 day period of organogenesis (day 6-15). The control group was given saline, 1ml/kg/day, on the same schedule. The litter sizes and conditions for each group were evaluated. No significant differences were found between control and test groups. DMMPA and DEMPA were not teratogenic at 0.1 or 1.0 LD50.

Descriptors :   *CHEMICAL AGENT SIMULANTS, *ORGANIC PHOSPHORUS COMPOUNDS, *MORPHOLINE, *TERATOGENIC COMPOUNDS, TOXIC HAZARDS, ORGANIC NITROGEN COMPOUNDS, RATS, PREGNANCY, ORAL DOSAGE, LETHAL DOSAGE, CONGENITAL ABNORMALITIES.

Subject Categories : Toxicology
      Chemical, Biological and Radiological Warfare

Distribution Statement : APPROVED FOR PUBLIC RELEASE