Accession Number : ADB044660

Title :   Prevention of Influenza and Other Respiratory Diseases.

Descriptive Note : Annual progress rept. 1 Feb 79-30 Jan 80,

Corporate Author : COLORADO UNIV HEALTH SCIENCES CENTER DENVER

Personal Author(s) : Meiklejohn, Gordon ; Eickhoff, Theodore C. ; Mostow, Steven R.

Report Date : FEB 1980

Pagination or Media Count : 26

Abstract : During the 1978-9 season H1N1 influenza was present on the base for 16 weeks, but incidence remained very low in the vaccinated population. The peak incidence of febrile respiratory disease in students was 7.2/1000/week. Cases of influenza occurred almost entirely in persons with H.I. antibody titers for A/Brazil/78 of less than 8. Military formula vaccine produced a moderately good antibody response in seronegative persons and a marked response in seropositive persons. The first injections of vaccine evoked an excellent response to A/Texas/77, a satisfactory response to B/Hong Kong/72 and a fair response to A/Brazil/77. The second injection of vaccine caused insignificant changes in titer for A/Texas/77 and B/Hong Kong/72, but a substantial increase in titers for A/Brazil/78, notably in persons whose titers remained low after the first injection. Other respiratory diseases caused little illness during the 1979-80 season. A few cases of adeno virus disease were detected, all in persons who had not received vaccine. Streptococcal infections accounted for about 15% of febrile U.R.I. A few viruses with the characteristics of echoviruses were isolated. Rubella and rubeola were not a problem.

Descriptors :   *RESPIRATORY DISEASES, *INFLUENZA VIRUS, *VACCINES, IMMUNIZATION, STUDENTS, ANTIBODIES, RESPONSE(BIOLOGY), PREVENTIVE MEDICINE, LEVEL(QUANTITY), RATES, DIAGNOSIS(MEDICINE), STATISTICAL DATA, TABLES(DATA).

Subject Categories : Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE