Accession Number : ADB060659

Title :   Prevention of Influenza and other Respiratory Diseases.

Descriptive Note : Annual progress rept. 1 Feb 80-30 Jun 81,

Corporate Author : COLORADO UNIV HEALTH SCIENCES CENTER DENVER

Personal Author(s) : Meiklejohn, Gordon ; Eickhoff, Theodore C. ; Mostow, Steven R.

Report Date : OCT 1981

Pagination or Media Count : 30

Abstract : The incidence of influenza A and B at Lowry AFB from 1977 to 1981 is reviewed. Following the large epidemic in 1978 of H1N1 influenza, when no vaccine was available, the H1N1 virus caused low incidence smouldering outbreaks in vaccinated personnel in 1979 and 1981. A small outbreak of influenza B occurred in 1978-79, affecting mainly permanent party. A few cases of H3N2 influenza occurred in 1977-78 and 1980-81. It appeared that vaccine was providing good levels of protection to military personnel in the face of large scale outbreaks in the surrounding civilian community. During the last 3 years, rates of febrile U.R.I. in students have at no time exceeded 8.8/1000/week. The 'protective' H.O. antibody level for H1N1 was above 64 when tested with A/Brazil/78 and was 16 when tested with A/Denver/81, a strain isolated at Lowry in 1981. Serum pairs for 200 recruits who received vaccine containing 14 microg each of A/Bangkok, A/Brazil and B/Singapore were tested to determine the adequacy of response. The response was satisfactory and indicated that only a single rather than a double immunization schedule was necessary. Comparison of methods for recovery of virus from throat washings were reviewed. For H1N1 strains, R.M.K. provided a 72 recovery rate and canine kidney only 36%. Isolation was difficult in chick embryo. Influenza B strains also were most readily isolated in R.M.K. No single serologic test was able to pick up all cases and it appears necessary to continue to use C.F. and H.I. tests, the latter including new strains and ether-split antigens. (Author)

Descriptors :   *RESPIRATORY DISEASES, *INFLUENZA VIRUS, *VACCINES, INFLUENZA, IMMUNIZATION, STUDENTS, ANTIBODIES, RESPONSE(BIOLOGY), PREVENTIVE MEDICINE, LEVEL(QUANTITY), RATES, DIAGNOSIS(MEDICINE), ANTIGENS, HEMAGGLUTINATION TESTS, STRAINS(BIOLOGY), BIOLOGICAL EXTRACTS, ADENOVIRUSES.

Subject Categories : Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE