Accession Number : ADB081473

Title :   Prevention of Influenza and other Respiratory Diseases.

Descriptive Note : Annual progress rept. 1 Feb 78-30 Jan 79,

Corporate Author : COLORADO UNIV AT DENVER MEDICAL CENTER

Personal Author(s) : Meiklejohn, G. ; Eickhoff, T. C. ; Mostow, S. R.

Report Date : FEB 1979

Pagination or Media Count : 45

Abstract : An explosive epidemic of H1N1 influenza occurred at Lowry AFB during February 1978. No H1N1 vaccine had been available and personnel under 25 were almost uniformly seronegative. Influenza (febrile) attack rates were estimated to be about 30% in students, who ranged in age from 17 to 23. An additional 20% were probably infected during the epidemic. The permanent party, most of which is over 25 years of age had far lower attack rates than the students. A small number of cases of H3N2 influenza occurred between 30 November 1977 and 30 January 1978, but the spread of this disease was very limited in this vaccinated population. The H1N1 virus strains differed from H3N2 strains in many ways. Isolation and identification were more difficult and lack of avidity of the prototype A/USSR/90/77 strain created difficulty in serodiagnosis. The most useful antigen for HI tests was an ether-split vaccine concentrate (PD) prepared from A/USSR/92/78 Surveys of HI antibody levels of military and civilian populations between 17 and 24 years of age indicated that approximately one half had been infected during or following the February 1978 epidemic. Studies of experimental H1N1 vaccines of 60 microgram and 20 microgram potencies showed that the former, whether split or whole virus, produced seroconversion in a very high proportion of persons.

Descriptors :   *INFLUENZA, *RESPIRATORY DISEASES, *IMMUNIZATION, EPIDEMIOLOGY, AIR FORCE FACILITIES, RATES, HEALTH SURVEYS, VACCINES, SEROLOGY, ANTIBODIES, DOSAGE, RESPONSE(BIOLOGY).

Subject Categories : Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE