Accession Number : ADB081493

Title :   Isolation of the Etiologic Agent of Scandinavian Epidemic (Endemic) Nephropathy from Human Patients (and from Wild Rodents) as Presumptive Strain in a Vaccine against Korean Hemorrhagic Fever).

Descriptive Note : Annual progress rept. no. 1, 1 Oct 81-30 Jun 82,

Corporate Author : UPPSALA UNIV (SWEDEN) DEPT OF INFECTIOUS DISEASES

Personal Author(s) : Friman, G. ; Rockborn, G. ; Dinter, Z.

Report Date : SEP 1982

Pagination or Media Count : 11

Abstract : In an effort to isolate the etiologic agent of Scandinavian epidemic (endemic) nephropathy (NE) for presumptive use in a vaccine against Korean hemorrhagic fever early drawn blood samples from patients suffering NE have been investigated. Samples were inoculated on to A-549 and VERO cell lines and into rodents. After several passages the materials were tested for the presence of antigen using an indirect immunofluorescence method. In addition, lungs of wild rodents from endemic NE areas have been tested for NE antigen. So far, results have been negative but with a combination of an even stricter selection of patients and of those methods applied the authors recommend the work should continue.

Descriptors :   *VACCINES, *HEMORRHAGIC FEVERS, *KIDNEY DISEASES, KOREA, ETIOLOGY, ISOLATION, SAMPLING, PATIENTS, SEROLOGY.

Subject Categories : Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE