Accession Number : ADB086227

Title :   Design and Synthesis of Candidate Prophylactic and Therapeutic Compounds for Use in the Management of Organophosphorus Poisoning.

Descriptive Note : Annual progress rept. no. 1, 1 Sep 81-31 Aug 82,

Corporate Author : ASH STEVENS INC DETROIT MI

Personal Author(s) : Blumbergs, P. ; Knutson, P. L. ; Priest, M. A. ; Pease, J. P. ; Stevens, C. L.

Report Date : OCT 1982

Pagination or Media Count : 47

Abstract : This program is directed at the design and synthesis of new compounds for use in the management of organophosphorus poisoning. In the past year 14 compounds were submitted for evaluation: nine organophosphinates, one oxophospholane, two aryl N-hydroxy-N-methycarbamates, one piperidine and one dialkylaminoalkyl glycolate ester.

Descriptors :   *POISONING, *ORGANIC PHOSPHORUS COMPOUNDS, *CHEMOTHERAPEUTIC AGENTS, PREVENTIVE MEDICINE, SYNTHESIS(CHEMISTRY), PHOSPHINATES, CARBAMATES, PIPERIDINES, ESTERS.

Subject Categories : Toxicology
      Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE