Accession Number : ADB086515

Title :   Design and Synthesis of Candidate Prophylactic and Therapeutic Compounds for Use in the Management of Organophosphorus Poisoning.

Descriptive Note : Rept. no. 2 (Annual) 1 Sep 82-31 Aug 83,

Corporate Author : ASH STEVENS INC DETROIT MI

Personal Author(s) : Stevens, C. L. ; Blumbergs, P. ; Knutson, P. L. ; Priest, M. A. ; Pease, J. P.

Report Date : APR 1984

Pagination or Media Count : 53

Abstract : The program is directed at the design and synthesis of new compounds for use in the management of organophosphorus poisoning. In the past year 16 compounds were submitted for evaluation: 11 organophosphinates, two aryl N-methoxy-N-methylcarbamates, a pyridinium carbamate and two sugar oximes, L-rhamnose oxime and D-digitoxose oxime.

Descriptors :   *CHEMOTHERAPEUTIC AGENTS, *ORGANIC PHOSPHORUS COMPOUNDS, *POISONING, SYNTHESIS(CHEMISTRY), PHOSPHINATES, OXIMES, CARBAMATES, SUGARS, MOLECULAR STRUCTURE.

Subject Categories : Toxicology
      Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE