Accession Number : ADB102436

Title :   Synthesis of New Antimalarial Agents.

Descriptive Note : Interim progress rept. 1 Apr-31 Jul 83,

Corporate Author : RESEARCH TRIANGLE INST RESEARCH TRIANGLE PARK NC

Personal Author(s) : Kepler, John A. ; Carroll, Frank I.

Report Date : AUG 1983

Pagination or Media Count : 35

Abstract : This report pertains to synthesis of New Antimalarial Agents. The objective of this project is to synthesize potential antimalarial compounds of the following types; Peroxides based on qinghaosu; Pro-drugs of primaquine; and Thymidylate synthetase inhibitors. This report describes the work carried out on this contract during the period April 1, 1983 to July 31, 1983.

Descriptors :   *ANTIMALARIALS, *PHARMACOLOGY, PEROXIDES, SYNTHASES, SYNTHESIS, PRIMAQUINE, ENZYME INHIBITORS.

Subject Categories : Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE