Accession Number : ADB106139

Title :   Easily Applied Long Lasting Dressing Based on Poroplastic (Trade Name) Materials. Phase IIB. Dual-Drug Dressing Incorporating Clindamycin with Gentamicin.

Descriptive Note : Annual rept.,

Corporate Author : MOLECULON RESEARCH CORP CAMBRIDGE MA

Personal Author(s) : Davidson, S. J. ; Obermayer, Arthur S. ; Nichols, Larry D. ; Hurd, Richard N. ; Allen, Marie B.

Report Date : 15 OCT 1984

Pagination or Media Count : 34

Abstract : Gentamicin-loaded Poroplastic membrane wound dressing of defined composition have been furnished to USAIDR, for in vivo evaluation. They have been shown to be effective for control of wound infections in vivo and their sustained release properties were found to contribute significantly to their in vivo effectiveness. Poroplastic preparations loaded with gentamicin and clindamycin have been developed, and their drug delivery properties studied in vitro. Certain of these preparations have been demonstrated to possess sustained release properties for both drugs. The release rates have been manipulated by varying various membrane and loading parameters. Thus, simultaneous controlled release for both drugs has been demonstrated in vitro. Conformability studies have been instituted. Keywords: Antibiotics.

Descriptors :   *ANTIBIOTICS, *DRESSINGS, DRUGS, IN VIVO ANALYSIS, PARAMETERS, CONTROL, RELEASE, SYNCHRONISM, INFECTIOUS DISEASES, WOUNDS AND INJURIES, DELIVERY, IN VITRO ANALYSIS, TEST AND EVALUATION, RATES.

Subject Categories : Medical Facilities, Equipment and Supplies
      Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE