Accession Number : ADB107113

Title :   Peripheral Neuropathy: Prevention and Treatment.

Descriptive Note : Annual summary rept. 15 Jul 83-14 Jul 84,

Corporate Author : MICHIGAN UNIV ANN ARBOR

Personal Author(s) : Richardson, Rudy J. ; Anderson, Rebecca J.

Report Date : 31 JUL 1984

Pagination or Media Count : 27

Abstract : Rats were dosed once daily with pyridostigmine (2 mg/kg) over a 20 day period. Groups of animals were assessed at intervals for changes in enzyme activity and nerve and muscle electrophysiologic activity. There was a marked inhibition of both acetylcholinesterase (AChe) and butyrylcholinesterase (BuChE) activity within 15 minutes of dosing. The activity recovered by 24 hours. There were no changes in nerve, spinal cord, or brain enzyme activity (AChE, BuChE, neurotoxic esterase, carboxylesterase). Likewise, there were no changes in the compound action potential of either the sural or sciatic nerve and no changes in the sciatic nerve responsiveness to extracellular potassium. The triceps surae muscles responded normally to tetanic stimulation during the course of the experiment. Initial work has begun, using 'ALZET' pumps to deliver constant infusions of either pyridostigmine or physostigmine.

Descriptors :   *PREVENTIVE MEDICINE, *CHEMOTHERAPY, *CHOLINESTERASE INHIBITORS, *PERIPHERAL NEUROPATHY, ACETYLCHOLINESTERASE, INFUSIONS, POTASSIUM, INHIBITION, PUMPS, SCIATIC NERVE, SPINAL CORD, BRAIN, ENZYMES, MUSCLES, PHYSOSTIGMINE, RATS, RESPONSE(BIOLOGY), STIMULATION(PHYSIOLOGY).

Subject Categories : Biochemistry
      Anatomy and Physiology
      Medicine and Medical Research
      Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE