Accession Number : ADB108556

Title :   The Screening and Evaluation of Experimental Antiparasitic Drugs.

Descriptive Note : Annual rept. 1 Feb 85-31 Jan 86,

Corporate Author : MIAMI UNIV FL LEO RANE RESEARCH LAB

Personal Author(s) : Ager, Arba L., Jr

Report Date : MAR 1986

Pagination or Media Count : 41

Abstract : These investigations included 2 antimalarial drug screens, and 2 African trypanosome drug screens, both of which are In vivo tests in rodent infections. The 2 antimalarial screens were: a primary blood schizonticidal test using Plasmodium berghei and a secondary drug screening system using rodent malaria and Anopheles stephensi mosquitoes. The 2 Africian trypanosome systems included a primary antitrypomastigote screen and a secondary drug-resistant screen, both using Trypanosoma rhodesiense. In the primary antimalarial blood schizonticidal test in 1,500 compounds were tested with 74 exhibiting activity. In the secondary screening system halofantrine, homoharringtonine, and quinghaosu were tested in a 6-day suppressive test. Seven tests were done to detect synergistic activity. Four drug-resistant lines have been passed without drug pressure for 54 months with their resistance remaining stable. Keywords: African trypanosomiasis tests; Pentamidines; Melarsoprols, Resistance(Biology).

Descriptors :   *ANTIPARASITIC DRUGS, *ANTIMALARIALS, ANOPHELES, CULICIDAE, DRUGS, IN VIVO ANALYSIS, INFECTIOUS DISEASES, MALARIA, PLASMODIUM BERGHEI, SECONDARY, SYNERGISM, TEST METHODS, TRYPANOSOMA, TRYPANOSOMIASIS, RESISTANCE(BIOLOGY).

Subject Categories : Medicine and Medical Research
      Microbiology
      Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE