Accession Number : ADB109038

Title :   Investigations Concerning Hydrolysis and Stabilization of Antiradiation Compounds.

Descriptive Note : Annual rept. 5 Jan 85-28 Jan 86,

Corporate Author : SOUTHWEST RESEARCH INST SAN ANTONIO TX

Personal Author(s) : Mangold, D. J. ; Swynnerton, N. F. ; Huelle, B. K. ; Lew, C. W. ; Miller, M. A.

Report Date : 28 JAN 1986

Pagination or Media Count : 197

Abstract : This report contains the results of the following studies: 1) Production or ethiofos microspheres/tablets and enteric-coated microcapsules/tablets for use as oral dosage forms. In vitro evaluation of the microsphere/microcapsule/tablet formulations for specific content and release of ethiofos. Development of analytical methodology for the determination of the following: Total convertible drug (e.g., ethiofos, WR-33278 and mixed disulfide conjugates, including cysteamine - WR-1065) to WR-1065; Cysteamine in plasma and urine; Equivalent ethiofis (14 C)-ethiofos in whole blood, plasma, urine and feces. Determination of hydrolysis rate constant for WR-3689. Pharmacokinetic assessment of intravenous, intraperitoneal and duodenal administration of ethiofos to the rhesus monkey.

Descriptors :   *HYDROLYSIS, *RADIOPROTECTIVE AGENTS, CONVERSION, DRUGS, DUODENUM, IN VITRO ANALYSIS, TEST AND EVALUATION, MIXING, SULFIDES, RHESUS MONKEYS, URINE, METHODOLOGY, MICROSPHERES, TABLETS(CHEMICAL), STABILIZATION, BLOOD, SYNTHESIS(CHEMISTRY).

Subject Categories : Radiobiology
      Organic Chemistry

Distribution Statement : APPROVED FOR PUBLIC RELEASE