Accession Number : ADB109535

Title :   Synthesis of Improved Antileishmanial and Antitrypanosomal Drugs Treatment and Prophylaxis.

Descriptive Note : Annual progress rept. no. 1, 1 Sep 84-31 Aug 85,

Corporate Author : ASH STEVENS INC DETROIT MI

Personal Author(s) : Markovac, A. ; Dagli, D. J. ; Kalamas, R. L. ; Ash, A. B. ; Stevens, C. L.

Report Date : NOV 1985

Pagination or Media Count : 24

Abstract : The program is directed at the preparation of improved antileishmanial and antitrypanosomal drugs. During the past year nine target compounds were submitted for testing against L. donovani, T. rhodesiense and T. cruzi. Four candidate antileishmanials are modified 8-aminoquinolines and one is a pyridyl bis(hydrazide). A bis(amidoxime)pyridylethylene, and bis(amidoxime)-bis(amidine) pair (modified commerical drug, diminazene) (berenil) are candidate trypanocides together with a 1-amidoximinomethyl-2,2-diarylethylene directed at T. cruzi.

Descriptors :   *ANTIPARASITIC DRUGS, TRYPANOCIDES, PREVENTIVE MEDICINE, SYNTHESIS(CHEMISTRY), QUINOLINES, PYRIDINES, AMIDINES.

Subject Categories : Biochemistry
      Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE