Accession Number : ADB111422

Title :   Design and Synthesis of Candidate Prophylactic and Therapeutic Compounds for use in the Management of Organophosphorus Poisoning.

Descriptive Note : Final rept. 1 Sep 81-30 Sep 84,

Corporate Author : ASH STEVENS INC DETROIT MI

Personal Author(s) : Blumbergs, P. ; Knutson, P. L. ; Priest, M. A. ; Pease, J. P. ; Stevens, C. L.

Report Date : MAY 1986

Pagination or Media Count : 90

Abstract : The program is directed at the design and synthesis of new compounds for use in the management of organophosphorus poisoning. In the past three years, 48 compounds were submitted: 26 organophosphinates, one organophosphinothioate, 2 organophosphonates, 2 organophosphates, one oxophospholane, 7 carbamates, 2 sugar oximes, 2 aminoalkylselenic and selonic acids and five other organic compounds. Keywords: Organophosphates; Carbamates; Prophylactics; Therapeutics; Antidotes.

Descriptors :   *ORGANIC PHOSPHORUS COMPOUNDS, *POISONING, *ORGANOPHOSPHATES, *CARBAMATES, *PREVENTIVE MEDICINE, ACIDS, MANAGEMENT, THERAPY, ORGANIC COMPOUNDS, SYNTHESIS(CHEMISTRY).

Subject Categories : Toxicology
      Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE