Accession Number : ADB114553

Title :   The Development of a System for Enhanced Radionuclide Detection.

Descriptive Note : Annual rept. 1 Aug 84-31 Jul 85,

Corporate Author : JOHNS HOPKINS UNIV BALTIMORE MD SCHOOL OF MEDICINE

Personal Author(s) : Pressman, Norman J. ; Frost, John K. ; Gupta, Prabodh K. ; Showers, Richard L. ; Gill, Gary W.

Report Date : NOV 1985

Pagination or Media Count : 127

Abstract : Toxicologic processes often involve extremely low concentrations of biologically active substances. These substances can be detected, localized and quantitated by attaching appropriate radiolabels and subsequently performing autoradiography for varying periods of time ranging from a few days to many months. The objective of this research was to demonstrate the feasibility of reducing this long data collection period to 10 to 100 times while maintaining the advantage of spatial resolution inherent in autoradiography. The operating parameters of a scintillation model were established and tested. A photon-limited camera and imaging system were selected and their characteristics optimized.

Descriptors :   *PHOTODETECTORS, *SCINTILLATION COUNTERS, *RADIOACTIVE ISOTOPES, *TOXICOLOGY, HISTOLOGICAL TECHNIQUES, TISSUES(BIOLOGY), BIOASSAY, ENERGY TRANSFER, LABELED SUBSTANCES, CAMERAS, IMAGE PROCESSING, CONCENTRATION(CHEMISTRY), AUTORADIOGRAPHY, MICROSCOPY, COMPUTER AIDED DIAGNOSIS, MATHEMATICAL MODELS, TOXICITY, IN VIVO ANALYSIS, SENSITIVITY.

Subject Categories : Toxicology
      Biochemistry

Distribution Statement : APPROVED FOR PUBLIC RELEASE