Accession Number : ADB117759

Title :   Development of Systems for Delivery of Antiviral Drugs.

Descriptive Note : Annual rept. 30 Sep 86-29 Sep 87,

Corporate Author : SOUTHERN RESEARCH INST BIRMINGHAM AL

Personal Author(s) : Shannon, William M. ; Secrist, John A., III ; Noker, Patricia E. ; Rose, Lucy M.

Report Date : OCT 1987

Pagination or Media Count : 50

Abstract : Ribavirin, a broad-spectrum antiviral agent with potent activity in vitro against a number of important RNA viruses of military significance, is severely limited in its usefulness against virus induced encephalitic diseases because it does not cross the blood-brain barrier well enough to achieve effective antiviral concentrations in the brain. Our efforts are directed toward the brain specific delivery of ribavirin and other antiviral agents by means of redox prodrug concept. The scope of the research program involves the synthesis of CNS-targeted prodrug ester of ribavirin and selenazole, pharmacokinetic studies of drug distribution and sustained delivery of drug in the brain, and the evaluation of the therapeutic efficacy of these antiviral prodrugs compared with the parent drugs in the treatment of lethal Venezuelan equine encephalitis (VEE) virus and Japanese encephalitis (JE) virus infections in mice. Additional in vivo studies with the other ribavirin prodrugs and the first selenazofurin prodrug are planned.

Descriptors :   *ANTIVIRAL AGENTS, *BRAIN, *PHARMACOKINETICS, *JAPANESE ENCEPHALITIS VIRUSES, *VENEZUELAN EQUINE ENCEPHALOMYELITIS VIRUS, BARRIERS, BLOOD, BROADBAND, CHEMOTHERAPEUTIC AGENTS, DISTRIBUTION, DRUGS, IN VITRO ANALYSIS, IN VIVO ANALYSIS, JAPANESE ENCEPHALITIS, MICE, RIBONUCLEIC ACIDS, SPECTRA, VENEZUELAN EQUINE ENCEPHALOMYELITIS VIRUS, VIRUS DISEASES, VIRUSES, MILITARY APPLICATIONS, BIOCHEMISTRY, SYNTHESIS(CHEMISTRY), LETHAL DOSAGE, VENEZUELAN EQUINE ENCEPHALOMYELITIS.

Subject Categories : Pharmacology
      Medicine and Medical Research
      Microbiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE