Accession Number : ADB119542

Title :   Synthesis of Nucleoside Analogues with Potential Antiviral Activity Against Negative Strand RNA Virus Targets.

Descriptive Note : Annual rept. 1 Sep 86-31 Aug 87,

Corporate Author : BIRMINGHAM UNIV (UNITED KINGDOM)

Personal Author(s) : Meacham, H. C. ; Wilcox, J. P.

Report Date : NOV 1987

Pagination or Media Count : 39

Abstract : The purpose of this work is to synthesis nucleoside analogues which are targeted against the replicase of negative-strand viruses. Two lines of investigation have been started: (i) the synthesis of 5-vinyl substituted pyrimidine ribonucleosides and (ii) the synthesis of potential ribonucleoside 5' -triphosphate analogues. A series of compounds of type (i) have been synthesised and submitted for biological evaluation. One compound of type (ii) has been made and further work is in progress. Keywords: Antiviral agents; Chemical analogs; Synthesis(Chemistry); Chemotherapy.

Descriptors :   *ANTIVIRAL AGENTS, BIOLOGY, CHEMICAL ANALOGS, CHEMOTHERAPY, SYNTHESIS(CHEMISTRY), TEST AND EVALUATION, NUCLEOSIDES, RIBONUCLEIC ACIDS.

Subject Categories : Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE