Accession Number : ADB119542
Title : Synthesis of Nucleoside Analogues with Potential Antiviral Activity Against Negative Strand RNA Virus Targets.
Descriptive Note : Annual rept. 1 Sep 86-31 Aug 87,
Corporate Author : BIRMINGHAM UNIV (UNITED KINGDOM)
Personal Author(s) : Meacham, H. C. ; Wilcox, J. P.
Report Date : NOV 1987
Pagination or Media Count : 39
Abstract : The purpose of this work is to synthesis nucleoside analogues which are targeted against the replicase of negative-strand viruses. Two lines of investigation have been started: (i) the synthesis of 5-vinyl substituted pyrimidine ribonucleosides and (ii) the synthesis of potential ribonucleoside 5' -triphosphate analogues. A series of compounds of type (i) have been synthesised and submitted for biological evaluation. One compound of type (ii) has been made and further work is in progress. Keywords: Antiviral agents; Chemical analogs; Synthesis(Chemistry); Chemotherapy.
Descriptors : *ANTIVIRAL AGENTS, BIOLOGY, CHEMICAL ANALOGS, CHEMOTHERAPY, SYNTHESIS(CHEMISTRY), TEST AND EVALUATION, NUCLEOSIDES, RIBONUCLEIC ACIDS.
Subject Categories : Pharmacology
Distribution Statement : APPROVED FOR PUBLIC RELEASE