Accession Number : ADB120959

Title :   Design, Synthesis and Study of Biomimetic Catalysts.

Descriptive Note : Final rept. 15 Mar 83-15 Sep 87; Annual rept. 16 Jun 86-15 Sep 87,

Corporate Author : ALBERTA UNIV EDMONTON DEPT OF CHEMISTRY

Personal Author(s) : Brown, Robert S.

Report Date : DEC 1987

Pagination or Media Count : 20

Abstract : Biomimetic catalysts modelled after the alkaline phosphatases and acid phosphatases were synthesized, and their catalysis of the hydrolysis of phosphate triesters was studied. The compounds fall into three classes: those that bind one divalent M2+-ion; those that bind two M2+ - ions; and those that contain an imidazole with a pendant guanidinium ion. The syntheses of the compounds in the former two classes is described along with the summary of in vitro assays. the Zn2+ and Co2+-chelates of these are respectable catalysts for hydrolysis of triesters. The guanidinium imidazoles are ineffective catalysts. Keywords: Biomimetic, Catalyst, Organophosphate ester, Alkaline phosphatase, Acid phosphatase, Chelates.

Descriptors :   *CATALYSIS, *CATALYSTS, *ESTERS, *HYDROLYSIS, *ORGANOPHOSPHATES, *SYNTHESIS(CHEMISTRY), ACID PHOSPHATASE, ACIDS, ALKALINITY, ASSAYING, CHELATE COMPOUNDS, GUANIDINES, IN VITRO ANALYSIS, IONS, PHOSPHATASES, PHOSPHATES, COBALT.

Subject Categories : Organic Chemistry
      Biochemistry

Distribution Statement : APPROVED FOR PUBLIC RELEASE