Accession Number : ADB122689

Title :   Testing of Experimental Compounds for Efficacy against Leishmania.

Descriptive Note : Annual rept. 1 Jan-31 Dec 87,

Corporate Author : GEORGIA UNIV RESEARCH FOUNDATION INC ATHENS

Personal Author(s) : Hanson, William L. ; Waits, Virginia B. ; Chapman, Willie L., Jr

Report Date : FEB 1988

Pagination or Media Count : 45

Abstract : A total of 309 new compounds of diverse chemical classes consisting of compounds with activity against other parasites, activity against viruses, or having chemical structures suggestive of being antimetabolites were studied in the primary visceral test system for suppressive activity against Leishmania donovani in golden hamsters. Seven of these were active. In comparison to the activity of the reference compound, Glucantime, one-half of these had activity approximately equal to Glucantime while the activity of the others was less than that of the reference compound. Keywords: Chemotherapy; WR06026; Chemoprophylactic; Antileishmanial agents. (KT)

Descriptors :   *LEISHMANIA, *PARASITES, ANTIMETABOLITES, CHEMOTHERAPY, HAMSTERS, MOLECULAR STRUCTURE, ORGANS(ANATOMY), SUPPRESSION, TEST AND EVALUATION, VIRUSES.

Subject Categories : Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE