Accession Number : ADB122935

Title :   Interferon Inducers against Infectious Diseases.

Descriptive Note : Annual rept. 23 Mar 87-22 Mar 88,

Corporate Author : HEALTH RESEARCH INC BUFFALO N Y

Personal Author(s) : Bello, Jake ; O'Malley, Judith

Report Date : 01 APR 1988

Pagination or Media Count : 36

Abstract : The double-stranded synthetic polynucleotide poly I poly C (i.e., poly-inosinic-poly-cyticylic acid, also to be called poly IC or IC) is an interferon (IFN) inducer. In primates it is not effective, presumably because of circulating nucleases which quickly degrade it. When complexed with cationic poly(L-lysine), PLL, and anionic carboxymethylcellulose, CMC, it is effective in humans. But CMC presents some difficulties: it is not excreted or metabolized, and it is suspected as a carcinogen (1). The problem being addressed in this research is the preparation of effective, safe IFN inducers devoid of CMC. To this end our main efforts have been to develop anionic polymers to replace CMC. We are also seeking to replace CMC by modifying the PLL with engrafted polysaccharides. Since CMC has undesirable features, including non-excretion, non-metabolization, and possible carcinogenicity, we are seeking formulations without CMC. We are exploring two approaches to this goal. One is the replacement of CMC with other anionic biopolymers, selected on the basis of known or expected safety, and being excretable or metabolizable. Keywords: Synthesis(Chemistry), (KT)

Descriptors :   *INTERFERON, *ANTIVIRAL AGENTS, ANIONS, CARBOXYMETHYLCELLULOSE, CARCINOGENS, FORMULATIONS(CHEMISTRY), HUMANS, INFECTIOUS DISEASES, POLYMERS, PRIMATES, SYNTHESIS(CHEMISTRY), PROTEINS.

Subject Categories : Organic Chemistry
      Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE