Accession Number : ADB123568

Title :   Development of Methods for Carrier-Mediated Targeted Delivery of Antiviral Compounds Using Monoclonal Antibodies.

Descriptive Note : Annual rept. 1 Apr 87-31 Mar 88,

Corporate Author : SRI INTERNATIONAL MENLO PARK CA

Personal Author(s) : Dawson, Marcia I. ; Sidwell, Robert W. ; Barnett, Bill B.

Report Date : APR 1988

Pagination or Media Count : 197

Abstract : SRI International and Utah State University are developing methodology to assess the effectiveness of antiviral drug-monoclonal antibody conjugate therapy for the treatment of viral infections. Specifically, monoclonal antibodies to Pichinde virus surface antigens were prepared and conjugated to the antiviral drug ribavirin, and the resulting conjugates will be screened for antiviral activity both in vitro and in animal model systems. Keywords: Binding sites, Antiviral agents, Monoclonal antibodies. (KT)

Descriptors :   *ANTIVIRAL AGENTS, *IN VITRO ANALYSIS, *VIRUS DISEASES, ANIMALS, ANTIBODIES, ANTIGENS, INFECTIOUS DISEASES, MEDICAL SERVICES, METHODOLOGY, VIRUSES.

Subject Categories : Pharmacology
      Organic Chemistry

Distribution Statement : APPROVED FOR PUBLIC RELEASE